Objective To improve the corrosion resistance of NiTi alloy and add strontium ions for the treatment of osteoporosis. Methods The mixture solution of sodium hydroxide and strontium nitrate was used for hydrothermal treatment of NiTi alloy. The treatment temperature was 180 ℃ and the treatment duration was 1 h, 3 h and 6 h, respectively. The microstructure and chemical composition of the samples were analyzed by scanning electron microscopy, energy dispersive of X-ray, X-ray diffraction and X-ray photoelectron spectroscopy. Hydrophilicity of the samples was assessed by contact angle measurement. The corrosion resistance was tested by potentiodynamic polarization test in the Ca-free Hank’s balanced salt solution, and the bonding strength of the hydrothermally prepared film on NiTi substrate was measured by pull-off test. Results Films con- sisting of strontium titanate particles were formed on NiTi alloy after the hydrothermal treatments, with the particles size ranging 240~490 nm, and small amount of nickel existed in the films. Water contact angle of the polished NiTi sample was 70°, and it was significantly increased to around 120° after the hydrothermal treatments. Within the passivation zone, the anodic current density of the hydrothermally treated (3 h) sample was decreased by about one order compared with that of the polished sample, and thus the hydrothermally treated sample had much better corrosion resistance. The apparent bonding strength value of the hydrothermally prepared (3 h) SrTiO3 film on NiTi substrate was 14.1 MPa. Conclusion The hydrothermal treatment improved the corrosion resistance of NiTi alloy, and the strontium ions added on the alloy surface could be used to treat osteoporosis.