In order to study the corrosion resistance and anti-corrosion mechanism of the self-healing coating which was prepared by adding corrosion inhibitors loaded mesoporous SiO2 microspheres into 7537 polyurethane. Method The benzotriazole (BTA) was loaded into SiO2 microspheres by negative pressure-impregnation method. The morphology and crystal structure of SiO2 microspheres and loading content of BTA were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and thermogravimetric analysis (TGA). The effect of SiO2, BTA, SiO2-BTA addition on corrosion resistance of the coatings were studied by potentiodynamic polarization curve measurement and electrochemical impedance spectroscopy (EIS). Results SEM images showed the size of SiO2 is approximately 1 μm. TGA showed the loading content of BTA is 32.38 wt%. According to immersion test, corrosion appeared on all kinds of coatings in the progress of immersion apart from the PU SiO2/BTA coating samples. The electrochemical polarization curve and EIS results showed that PU+SiO2/BTA coating samples always has the lowest current density and higher impedance values.