Objective To solve the problem that the concrete structure of the road damage seriously under the interaction of the fatigue load and the sulfate corrosion. Methods in this paper, using self-developed corrosion fatigue device, we mainly studied the distribution of sulfate ions and the strength variation rule of road concrete subjected to corrosion for 180d under the condition of different load types (alternating load and static load)、different sulfate species (MgSO4 and Na2SO4)、different sulfate concentration (5% and 10% Na2SO4)、different stress levels (20%, 40% and 60%)、different water-cement ratio (0.35 and 0.38) by chemical analysis and strength test method. At the same time, the surface of the concrete was coated with silane, and the anti-fatigue performance of the concrete was tested. Results the sulfate ion penetration speed of the road concrete subjected to corrosion fatigue is 1.43 times of the specimen subjected to sustained loading. Under the effect of corrosion fatigue, the sulfate ion erosion rate increased by nearly 1 times when the sulfate concentration increased by 1; The sulfate concentration increased from 2.51% to 4.62% when the stress level increased from 0.2 to 0.6; The sulfate ion diffusion speed reduced by 17% when the water cement ratio fell from 0.38 to 0.35. Since Mg(OH)2 generated from magnesium has low solubility, the effect of magnesium sulfate on the surface layer of concrete is 70% of the sodium sulfate; The flexural tensile coefficient of the coated silane concrete is increased by nearly 40% compared with that of the uncoated specimen. Conclusion The fatigue load exacerbated the sulfate corrosion of concrete; In the corrosion fatigue environment, appropriate reduction of the water cement ratio as well as the adoption of the silane coating technology can greatly improve the concrete resistance of concrete and and prolong the service period of concrete.