Objective To reduce the interference of stray current on natural gas pipeline of Nanlang segment, and eliminate the stray current corrosion risks. Methods Detection of stray current interference on natural gas pipeline of Nanlang segment was conducted by cathodic protection potential test and SCM detection technology. According to the test results, discharge of stray current was designed and transformed. Six discharge points were designed in the 009—019 test pile, and the drainage technology was implemented using the solid state decoupling device. After the completion of the transformation, the effectiveness of the implementation was verified. Results The detection result showed that the maximum disturbance of stray current was 16. 839 V, the stray current density was 393 A/ m2, and the interference length was 8 km. The stray current interference came from the electrified railway. There was stray current interference during the railway running time, and no stray current interference during the railway outage time. After the transformation was completed, the stray current interference voltage dropped to below 4 V. Conclusion The practical application of the drainage technology effectively reduced the stray current interference on natural gas pipeline of Nanlang segment, and the national standard was attained. The risk of the stray current corrosion was eliminated, ensuring the safety operation of natural gas pipeline of Nanlang segment. The detection and drainage technology of stray current interference could be used to eliminate the influence of railway on the stray current corrosion of the buried pipeline. and is of demonstration significance for the protection of pipelines affected by the newly built charged structure.