Objective To determine the optimal MAO technological parameters and to improve the the anti-oxidation property of Ti alloy at high temperature. Methods The orthogonal table of L9(33 ) was used to design the test. The coating structure and phase were characterized by SEM and XRD, respectively. Thermal cyclic oxidation at 650 ℃ for 100 h was carried out to evaluate the anti-oxidation property of the coating at high temperature. Range analysis was used to sort the MAO technological parameters according to their effects on the oxidation weight gain of the coating sample, obtaining the combination of optimal parameters. Mathematical model was built between the oxidation weight gain and technological parameters by regression analysis, and the significance of the model was analyzed. Results The surface morphology characteristics of MAO coatings prepared with different technological parameters was different, and the major phases of TiO2 in the coating were rutile and anatase phases. The effects of the three factors on the anti-oxidation property of the coating at high temperature were in the order of voltage>time>electrolyte concentration. The quadratic function equation model established between the oxidation weight gain and different parameters (voltage V, reaction time t, electrolyte concentration E) was W = 0. 008 39 (V-396. 6) +0. 1698t -64. 5E -0. 000 108 ( V -396. 6) 2 -0. 0044t2 +700E2 + 0. 0017. Conclusion The optimized combination of technological parameters was: voltage 480 V, reaction time 25 min, electrolyte concentration 0. 04 mol / L. The mathematical model obtained from the oxidation weight gain and different parameters through regression analysis was significant.