Objective To study the modification effect of microwave discharge of PDMS materials. Methods PDMS was activated by the low-temperature plasma discharge produced by household microwave oven and the self-made vacuum hood electrode device. The recovery of the surface contact angle and the bonding strength of the modified PDMS were experimentally tested. Results After microwave discharge treatment, the PDMS surface showed strong hydrophilicity at the beginning, when the microwave power was 140 W and the working time was 5 s, the PDMS surface contact angle could reach 10°. Through observation, it was found that with the increase of storage time, the PDMS surface contact angle increased gradually and after 10 d it returned to the original hydrophobic angle state. At the same time, good bonding was achieved between the modified PDMS samples, and the optimal bonding condition was 80 ℃ for 1. 5 h, under this condition the bonding strength could reach 12. 4 N. Conclusion After treatment with microwave discharge method, the PDMS materials surface could be successfully modified to be hydrophilic, and good bonding could be achieved between PDMS. Compared with the traditional plasma processing bonding method, this method is simple, economic and efficient.