Objective To synthesize glyphosine and study the corrosion inhibition performance of glyphosine and its mixture. Methods Glyphosize was synthesized with phosphate, formaldehyde and glycine in acidic solution. The corrosion inhibition performance of LY12 alloy in glyphosine solution under acidic condition was studied by Tafel curves and electrochemical impedance spectroscopy. And glyphosine was compared with the similar phosphonic acid, i. e. , amino trimethylene phosphonic acid (ATMP). Besides, the corrosion inhibition performance of LY12 alloy was studied in glyphosine solution. Results When the pH=1, the mass concentration of glyphosine was 0. 5% , the corrosion inhibition rate was up to 90% . And the corrosion inhibition effect of glyphosine solution was superior to ATMP under the same acidity and the same concentration of corrosion inhibitor. The corrosion inhibition effect of glyphosine was not ideal while used alone in alkaline condition. However, when it was mixed with trolamine, the corrosion inhibition effect was preferable. When the pH = 8. 7 and the built-up concentration was 0. 5% trolamine with 0. 4% glyphosine, the corrosion inhibition rate of LY12 alloy was up to 65. 5% . Conclusion The corrosion inhibition effect of glyphosine was excellent when used alone under acidic condition. Its corrosion inhibition effect was preferable when it was mixed with trolamine under alkaline condition.