Objective To design the formula of low-loss coatings for large core energy fiber and discuss its application. Methods Using vinyl silicone oil, mercapto silicone, Trifluoroethyl methacrylate ( TRIFEMA), 1H, 1H, 11H-perfluoroundecyl acrylate (FA), Viton, Tetrahydrofurfuryl acrylate GM61P00 (THFA) and Polyurethane acrylate (PU) as the main ingredients, fiber coatings with different formulations were designed, and the refractive index, transmittance, gel content and fiber transmission loss were tested to screen for the optimal formula. Results The optimal proportion of coating for low-loss large core energy fiber was m(vinyl silicone oil): m(sulfydryl silicone oil ) : m(TRIFEMA) = 27: 5: 1. The refractive index was 1. 392, and the transmittance was 99. 23% (when the wavelength was 850 nm), the strength of extension and transmission loss of the obtained low-loss large core energy fiber were 4392 MPa and 6. 6 dB / km, respectively. Conclusion Perfluorinated compounds could lower the refractive index of the coating, but it had defects in curing, leading to high fiber loss. Fluorine and silicone coating had excellent wetting properties and strong coating adhesion, besides, the various performance indicators all met the operating requirements of optical fiber.