Objective To set up a test unit for full-size corrosion simulation. Methods According to the comprehensive consideration of various factors affecting CO2 corrosion in CO2 flooding oil field, an advanced simulation test device was designed and developed for high-temperature and high-pressure CO2 corrosion examination. A variety of experimental studies focusing on the corrosion characteristics of materials and anticorrosion properties of corrosion inhibitors were carried out under different simulation conditions using this device, and the evaluation data were comparatively analyzed with the data obtained in indoor autoclave experiment and by field corrosion monitoring. Results Various field site corrosion conditions could be simulated with the conditions of liquid CO2 flow rate of 0 ~ 0. 9 m3 / h, temperature of -25 ~ 120 ℃ , and the max pressure of 32 MPa. The device developed in this work could more effectively simulate the multiphase flow state of CO2 flooding both at low temperature and high temperature and high pressure conditions, which was not able to be accomplished by the usual test devices. The flow state obtained was closer to the field flow state, and the simulation result could effectively guide the establishment of anticorrosion technology for CO2 flooding oil and buried storage projects. Conclusion The CO2 corrosion simulation data obtained in the device under the surface field site condition was close to the actual corrosion monitoring data in the field site. A combined field site evaluation could be set up based on these simulating tests on corrosion and anti-corrosion behavior of wellbore, ground equipment and / or pipe materials.