目的 镁合金作为骨植入材料在临床上的应用受到广泛关注，然而骨植入术后的恢复问题长期以来未得到解决。方法 以Mg-6Zn合金为基体，基于简便的微弧氧化工艺，通过添加纳米铜粉，制备了含Cu²⁺的镁合金涂层，研究了不同纳米铜添加量下涂层的耐腐蚀、抗肿瘤和成血管性能。结果 Cu²⁺的加入，使涂层表面形貌得到改善，涂层更加平整致密，0.35 g/L添加量下，其拥有(385.46±38.99)HV的显微硬度、(3.90±0.28)%的孔隙率和最小(1.40±0.86) μm的孔径。在耐腐蚀性能测试中，表现出了最低的腐蚀速率(3.14′10^?5 mm/a)，较不含Cu²⁺涂层降低了1个数量级。体外实验表明:Cu²⁺涂层具有良好的生物相容性，骨髓间充质干细胞的增值率大于80%，溶血率低于4%，细胞黏附效果良好。此外，Cu²⁺涂层还具备较好的抗肿瘤和成血管能力，培养大鼠骨肉瘤细胞时，其增值率低至(24.53±2.75)%。在合适的浓度下，Cu²⁺能够实现抗肿瘤和成骨的协同作用;同时，Cu²⁺又会促进血管内皮细胞生长因子的分泌，刺激细胞增殖分化，进而促进血管生成;而在肿瘤条件下，Cu²⁺又会延迟血管内皮细胞成血管。结论 Cu²⁺具有良好的氧化活性，会使肿瘤细胞铜过载而产生氧化应激反应，进而死亡，并且Cu²⁺还能上调血管内皮细胞的生长因子，促进细胞增殖进而血管化。因此，这种具备较好耐腐蚀性、抗肿瘤和成血管能力的含Cu²⁺医用镁合金涂层，有望在骨植入及其术后问题上得到实际应用。

Infection and recovery problems after bone implantation have long limited the clinical application of bone implant materials such as magnesium alloys. In order to better meet the clinical needs, the work aims to prepare a Cu2+-containing magnesium alloy coating with Mg-6Zn alloy as a substrate by adding copper nanopowder based on a facile micro-arc oxidation process. The surface morphology of the coating was characterized with a ZEISS EVO MA15 scanning electron microscope and a ZEISS EVO MA15 energy spectrometer. The corrosion resistance of the sample was tested by an AUTOLAB PGSTAT302 electrochemical workstation. The value-added rate of the bone marrow mesenchymal stem cells of rats was evaluated with a Cell Counting Kit-8 kit, and the biocompatibility of the sample was assessed through observation of the adhesion morphology with a Nikon A1R laser confocal microscope. The Cell Counting Kit-8 was employed to assess the value-added rate of osteosarcoma cells in rats and observe their adhesion morphology via the Nikon A1R laser confocal microscope, thereby evaluating the anti-tumour efficacy of the sample. Calcein/PI Cell Activity A Cytotoxicity Assay Kit was employed to stain the vascular endothelial cells of rats, and a Leica inverted fluorescence microscope was used to observe their adhesion morphology, thus enabling an evaluation of the vasculogenic ability of the sample.