目的 为解决镁合金血管支架使血管内皮化、造成再狭窄等问题，在AZ31镁合金表面制备具有抗凝特性的肝素(HS)/蒙脱石(MMT)复合涂层，并研究其耐蚀性能。方法 采用水热法在AZ31镁合金表面制备钠蒙脱石(Na-MMT)涂层，在此基础上通过浸泡法以蒙脱石为载体，制备肝素/蒙脱石复合涂层。利用扫描电子显微镜(SEM)、傅里叶红外光谱仪(FT-IR)、X射线衍射仪(XRD)对所得涂层进行表面分析，通过电化学分析和析氢速率测定研究涂层的耐蚀性。结果 表面分析结果显示，通过水热法和浸泡法得到了均匀致密的HS-MMT涂层，厚度为41 mm。HS-MMT涂层的EDS元素分析图中出现了N、S及蒙脱石的基本元素，同时该涂层的FT-IR和XRD图出现了肝素及蒙脱石的特征峰。耐蚀性研究显示，与AZ31镁合金相比，HS-MMT涂层的自腐蚀电位升高了0.29 V，腐蚀电流密度降低了2个数量级，且其平均析氢速率为0.016 mL/(cm×h)，仅为AZ31镁合金平均析氢速率的18%。 结论 采用水热法和浸泡法在AZ31镁合金表面成功制备了HS-MMT涂层，该涂层具有良好的耐蚀性能，为镁合金血管支架的研究提供了一种新方案。

To solve the problems such as vascular endothelialization and restenosis caused by magnesium alloy stent, this study aims to prepare heparin (HS)/montmorillonite (MMT) coating with anticoagulant properties on biomedical magnesium alloy and investigate its corrosion resistance. Sodium montmorillonite (Na-MMT) coating was prepared on the surface of AZ31 magnesium alloy by hydrothermal method; and then HS/MMT composite coating was prepared by immersion method. The coating was characterized using scanning electron microscopy (SEM), Fourier infrared spectroscopy (FT-IR) and X-ray diffractometry (XRD). The corrosion resistance of the coating was investigated by means of electricchemical analysis and hydrogen evolution rate measurement. The results showed that the prepared HS-MMT coating was uniform and compact, with coating thickness of 41 mm. The basic elements of montmorillonite and N, S were found in the EDS analysis diagram of HS-MMT coating, and the characteristic peaks of heparin and montmorillonite were found in the FT-IR and XRD images of the coating. Compared with the AZ31 magnesium alloy, the free corrosion potential of HS-MMT coating was increased up to 0.29 V; corrosion current density was decreased by two orders of magnitude; and the average hydrogen evolution rate was 0.016 mL/(cm×h), only 18% of the AZ31 substrate. Therefore, the HS-MMT coating has good corrosion resistance, providing a new scheme for magnesium alloy vascular stents.