| MENG Xiao-li,LYU Ping,CUI Xu-dong,HE Xue-bin,MA Sheng-qiang,XING Jian-dong.Research Progress of Biodegradable Zinc Alloys for Bone Implants[J],51(10):66-75 |
| Research Progress of Biodegradable Zinc Alloys for Bone Implants |
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| DOI：10.16490/j.cnki.issn.1001-3660.2022.10.008 |
| KeyWord:biodegradable zinc alloy mechanical properties deformation processing degradation behavior biocompatibility |
| Author | Institution |
| MENG Xiao-li |
State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an , China;Shaanxi Union Research Center of University and Enterprise for Zinc-based New Materials, Xi'an , China |
| LYU Ping |
State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an , China;Shaanxi Union Research Center of University and Enterprise for Zinc-based New Materials, Xi'an , China |
| CUI Xu-dong |
Shaanxi Union Research Center of University and Enterprise for Zinc-based New Materials, Xi'an , China;Shaanxi Zinc Industry Co., Ltd., Shaanxi Shangluo , China |
| HE Xue-bin |
Shaanxi Union Research Center of University and Enterprise for Zinc-based New Materials, Xi'an , China;Shaanxi Zinc Industry Co., Ltd., Shaanxi Shangluo , China |
| MA Sheng-qiang |
State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an , China;Shaanxi Union Research Center of University and Enterprise for Zinc-based New Materials, Xi'an , China |
| XING Jian-dong |
State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an , China |
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| Abstract: |
| Biodegradable zinc alloy is a new and promising material for human bone implants. Its degradation rate conforms to the degradation rate standard of human implants and has good mechanical properties and biocompatibility. This paper briefly introduces the development potential and application prospects of biodegradable zinc alloys as bone implant materials in terms of mechanical properties, corrosion degradation behavior and biocompatibility. The effects of the selection and addition of different alloying elements on the toughening, biodegradability and biocompatibility evaluation of biodegradable zinc alloys in recent years are emphatically reviewed. At the same time, the effect of plastic deformation process on the mechanical properties of biodegradable zinc alloy was discussed. In addition, this overview also investigates the requirements of the in vitro and in vivo degradation behavior and biocorrosion mechanism of biodegradable zinc alloys, and briefly discusses the biocompatibility of biodegradable zinc alloys from the aspects of cell response, blood compatibility, tissue immunity. The effects of various enhancement methods on biodegradable zinc alloys are clarified, and the advantages and disadvantages of various methods are analyzed and discussed. In view of the problems existing in the current preparation technology, combined with the existing research results, the future development direction of bio-zinc alloys is pointed out. The enhancement methods of bio-zinc alloys, such as alloying, changing the addition amount, deformation processing operations, and surface modification treatments, can effectively improve the comprehensive properties of pure zinc. Alloying builds binary alloys or multi-component alloys, which play a role in fine-grain strengthening of the matrix and improve strength and hardness. The selection of the addition amount combined with comprehensive tests such as in vitro and in vivo experiments and biocompatibility tests show that the appropriate addition amount can induce osteoblast differentiation without causing cytotoxicity, but excessive additions such as Li, Al, Ag may cause a series of human disease. Deformation processing processes such as extrusion, cumulative extrusion, and cold drawing are strengthened by changing grain morphology and dynamic recrystallization, and the cumulative extrusion process can significantly enhance mechanical properties. It can be seen from the degradation behavior and corrosion mechanism in vitro and in vivo that the zinc alloy has a moderate degradation rate and does not generate hydrogen gas pockets. The degradation products can act as a protective layer, which helps to improve cell adhesion and enhance antibacterial ability. The osteogenic ability, serum level, and cell survival rate of zinc alloys implanted in organisms are closely related to the release of zinc ions. The amount of zinc ions released by zinc alloys is generally within the safe threshold range and will not cause cytotoxicity. Surface modification technology can further regulate the release of zinc ions. The preparation method of ZnP coating is simple, which is an effective means to reduce the release of zinc ions and can effectively improve the biocompatibility. At present, some progress has been made in biodegradable zinc alloys in biological implants. However, the mechanical properties and biocompatibility of biodegradable zinc alloys are still the direction of efforts for a long time. In the future, based on the advantages of the existing enhancement methods of biodegradable zinc alloys, the development of new enhancement methods and in vivo dynamic simulation tests and performance evaluation methods are all important development trends in the future. |
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