| PENG Lan,ZHANG Guo-fen,LUO Di-di,WANG Qin,GAN Ying-rui,ZHU Yu-fa,LIU Qi-bin.Effects of Different Ca/P on Properties of Bioceramic Coating Prepared by Broadband Laser Cladding[J],51(7):363-369 |
| Effects of Different Ca/P on Properties of Bioceramic Coating Prepared by Broadband Laser Cladding |
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| DOI：10.16490/j.cnki.issn.1001-3660.2022.07.036 |
| KeyWord:laser cladding Ca-P coating microstructure biocompatibility bioactivity |
| Author | Institution |
| PENG Lan |
College of materials and metallurgy, Guizhou University, Guizhou Guiyang , China |
| ZHANG Guo-fen |
College of materials and metallurgy, Guizhou University, Guizhou Guiyang , China |
| LUO Di-di |
College of materials and metallurgy, Guizhou University, Guizhou Guiyang , China |
| WANG Qin |
College of materials and metallurgy, Guizhou University, Guizhou Guiyang , China |
| GAN Ying-rui |
College of materials and metallurgy, Guizhou University, Guizhou Guiyang , China |
| ZHU Yu-fa |
College of materials and metallurgy, Guizhou University, Guizhou Guiyang , China |
| LIU Qi-bin |
College of materials and metallurgy, Guizhou University, Guizhou Guiyang , China |
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| Abstract: |
| This paper aims to study the performance of broadband laser cladding bioceramic coatings with different wCa/wP, explore the influence of wCa/wP on coating hardness, biocompatibility and biological activity and seek the optimal experimental parameters to provide a reference for the future preparation of coatings with excellent performance. In biomedical implant materials, bioceramic coatings prepared by laser cladding technology on titanium alloy surface have attracted wide attention due to their excellent mechanical properties and osteogenic properties. At present, relevant studies only focus on the influence of La2O3 and SiO2 doping amount on the formation of HA+TCP and coating biological properties, and do not involve the influence of different wCa/wP on coating properties. Therefore, this paper adopts the broadband laser cladding technology and the composition gradient design idea. The titanium alloy Ti-6Al-4V is used as the matrix material, the coating material is CaHPO4.2H2O, CaCO3 and Ti powder, and the doping materials are selected as 0.6wt.% La2O3 and 10wt.% SiO2. This paper adopted to gradient design idea, using broadband laser cladding technology. Gradient bioceramic coatings with wCa/wP of 1.35, 1.40 and 1.45 were prepared. And by using X-ray diffractometer (XRD), scanning electron microscope (SEM), metallographic microscope, microhardness tester, simulated body fluid immersion test, in vitro cell test, system research different wCa/wP of biological ceramic coating structure, the effects of different wCa/wP on the coating structure, biocompatibility and bioactivity of bioceramic coatings were studied. the influence of the biocompatibility and bio activity, to seek the optimal experimental parameters, provide a reference for future preparation of high performance coating. XRD shows that the coating is mainly composed of CaTiO3, HA, Ca2SiO4, CaO and TCP phases. When wCa/wP=1.40, the number of HA+TCP is the largest. Hardness test shows that the higher the wCa/wP is, the higher the average hardness of the coating is. The coating with wCa/wP=1.45 has fewer cracks and the highest average microhardness, while the coating with wCa/wP=1.35 has the lowest average hardness. In vitro cell experiments showed that MG63 cells on all the coatings were evenly distributed and had good growth morphology, indicating that all the coatings had no toxicity to cells. Among them, The OD value of the coating with wCa/wP=1.40 increased rapidly, and the OD value measured on the fifth day of co-culture was much higher than that of other coatings, and the OD value increased the most compared with that on the first day. SBF solution immersion experiment showed that the three wCa/wP ceramic coatings were covered with osteoid apatite on the surface. The coating with wCa/wP=1.40 was covered with the most osteoid apatite after soaking. It was found that many filamentous pseudopods of the cells were closely attached to the coating, so that the cells could adhere to the coating and grow, and showed a normal spindle shape with relatively complete cell membrane. The coating with wCa/wP=1.40 adhered to more cells and distributed more evenly. In conclusion, when wCa/wP=1.40, wCa/wP bioceramic coating not only has good biomineralization ability and can form more bone-like apatite, but also has the largest number of cells proliferated and adsorbed on the coating, showing good bioactivity and biocompatibility. |
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