| QI Qi,WANG Hong-fen,CHEN Shou-gang.Preparation and pH Sensitivity of Polyaniline Composites Doped with Different Acids[J],50(4):267-274 |
| Preparation and pH Sensitivity of Polyaniline Composites Doped with Different Acids |
| Received:May 05, 2020 Revised:June 08, 2020 |
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| DOI：10.16490/j.cnki.issn.1001-3660.2021.04.027 |
| KeyWord:Titanium dioxide nanotubes polyaniline acid doping pH sensitivity drug release |
| Author | Institution |
| QI Qi |
Ocean University of China, Qingdao , China |
| WANG Hong-fen |
Ocean University of China, Qingdao , China |
| CHEN Shou-gang |
Ocean University of China, Qingdao , China |
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| Abstract: |
| In this paper, the effect of acids doping on the pH sensitivity of polyaniline-coating drug-loaded TiO2 nanotubes (PANI@TNTs-BIT) was explored. The PANI@TNTs-BIT composites were prepared by chemical oxidation polymerization, with CA, L-Glu, and LABSA as doping acids, respectively. The structures and morphologies were characterized by XRD, TEM and FT-IR. At the same time, the drug loading of the composites was determined by TGA test. The absorbance of BIT drug at 225 nm wavelength was measured by the UV-vis method, and the functional formula between its absorbance and concentration was deduced, which was used to reveal the drug release amount of the composites in different pH environments. The results showed that anatase TNTs can act as nano-containers of BIT, and the drug loading rate reaches up to 23%. After being wrapped with PANI coating, the drug loading rate of BIT decreases to 9.8%, which indirectly reflects a thick PANI coating on TNTs-BIT, and this is further confirmed by TEM images. Furthmore, the acid-doped PANI@TNTs-BIT composites showed an excellent pH sensitivity. As the pH of environment decreases (from 8.5 to 5.8), the release amount of BIT from PANI@TNTs-BIT doped with L-Glu and LABSA shows a rapid growth trend. Especially, the composite doped with LABSA not only shows excellent pH-responsive drug release behavior, but also obviously alleviates the “burst release” problem, showing an excellent antifouling property. It concludes that anatase TNTs can alleviate / control the release of the loaded BIT drugs, and after coating TNTs-BIT with PANI doped with L-Glu and LABSA, the drug loading system can respond to the change of environmental pH in time, so as to intelligently control the drug release and achieve the purpose of antifouling. |
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