| REN Hao-zheng,PAN Chao,XU Ying,SUN Xiao-hao,LIU De-bao.Study on Zn-Cu Tissue Engineering Scaffolds Surface Modified by ZnO[J],50(2):58-65 |
| Study on Zn-Cu Tissue Engineering Scaffolds Surface Modified by ZnO |
| Received:October 23, 2020 Revised:December 23, 2020 |
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| DOI：10.16490/j.cnki.issn.1001-3660.2021.02.007 |
| KeyWord:Zn-Cu alloy porous scaffolds ZnO coating hydrophilicity antibacterial properties |
| Author | Institution |
| REN Hao-zheng |
College of Material Science and Engineering, Tianjin University of Technology, Tianjin , China |
| PAN Chao |
College of Material Science and Engineering, Tianjin University of Technology, Tianjin , China |
| XU Ying |
College of Material Science and Engineering, Tianjin University of Technology, Tianjin , China |
| SUN Xiao-hao |
College of Material Science and Engineering, Tianjin University of Technology, Tianjin , China |
| LIU De-bao |
College of Material Science and Engineering, Tianjin University of Technology, Tianjin , China |
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| Abstract: |
| Modern tissue scaffolds materials are not only required to possess a certain mechanical properties and excellent biocompatibility, but also required to have a surface presenting good hydrophilicity and certain antibacterial properties. In this work, Zn-xCu (x=0,1,2,3) alloy tissue engineering scaffolds with theoretical porosity of 60% were successfully prepared by using air pressure infiltration method (APIM) and the surface of Zn-xCu (x=0,1,2,3) tissue engineering porous scaffolds were modified with ZnO by hydrothermal method. The macrostructures, microstructures and phase composition of the porous scaffolds were characterized by means of a field emission scanning electron microscope and X-ray diffractometer respectively. The hydrophilicity/hydrophobicity of the material surface was evaluated by measuring the contact angle between the material surface and water by drop method. The antibacterial properties of the scaffolds materials before and after the surface modification of ZnO were studied by using the bacterial paving method. The results show that:the pores are interconnected and distributed homogeneously within all the prepared scaffolds; the surface of the scaffolds without ZnO modification shows strong hydrophobicity, and the wettability of the scaffolds modified with ZnO is significantly improved; and the modified Zn-3Cu scaffolds have better antibacterial properties. The longest effective distance of Zn-3Cu scaffolds without ZnO surface modification is 7.8 mm, and the longest effective distance of Zn-3Cu scaffolds after ZnO surface modification is 9.8 mm. In addition, compared with the blank control bacterial solution, the modified Zn-3Cu scaffolds material extract co-cultured with the bacterial solution, has sparse and loose bacterial colony after scribing and coating. Therefore, Zn-Cu alloy tissue engineering scaffolds with certain antibacterial properties and hydrophilic surface can be prepared by using the APIM with ZnO surface modification. |
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