| MA Huan-huan,QIU Wen-hao,HUANG Hao,QIAO Yang.Research Progress in Biological Modification of Polyether-ether-ketone Bone Implants[J],52(3):111-121 |
| Research Progress in Biological Modification of Polyether-ether-ketone Bone Implants |
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| DOI：10.16490/j.cnki.issn.1001-3660.2023.03.008 |
| KeyWord:PEEK bone implants mechanical property osseointegration property mold resistance |
| Author | Institution |
| MA Huan-huan |
School of Mechanical Engineering, University of Jinan, Jinan , China |
| QIU Wen-hao |
School of Mechanical Engineering, University of Jinan, Jinan , China |
| HUANG Hao |
School of Mechanical Engineering, University of Jinan, Jinan , China |
| QIAO Yang |
School of Mechanical Engineering, University of Jinan, Jinan , China |
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| Abstract: |
| Polyether-ether-ketone (PEEK) is a thermoplastic material that is widely used in biomedical fields due to its good biocompatibility and X-ray transmittance. However, there is a certain gap between PEEK implants and human bone strength, and the poor binding ability to human bone tissue and the lack of antibacterial properties limit their application in the biological field. The osseointegration and antibacterial properties of implant materials are critical to the success of human therapy, repair and surgery. In order to make PEEK better used in the field of human bone implantation, obtaining PEEK bone implants with excellent performance has become the focus of research. This paper summarizes the research on the processing technology, mechanical properties, osseointegration properties and antibacterial properties of PEEK. On this basis, the research progress of PEEK processing technology and various modification methods to improve the mechanical properties and biological properties of PEEK in recent years is mainly reviewed. First, the effects of 3D printing and machining on the surface quality of PEEK machined are outlined. In the cutting process, the influence of cutting parameters and cooling medium on the quality of the machined surface is mainly expounded. In 3D printing, the research on the strength and surface quality of printed parts by process parameters such as printing speed, nozzle temperature and heat treatment method is detailed. Secondly, in terms of improving the mechanical properties of PEEK, the carbon fiber filled PEEK is mainly summarized. Due to the chemical inertness of carbon fiber and the high melt viscosity of PEEK, the bonding force between the interface of PEEK and carbon fiber is weak, which affects the overall mechanics of carbon fiber PEEK composites. Therefore, the modification method to improve the force of the bonding surface of PEEK and carbon fiber is emphasized. Thirdly, the osseointegration properties and antibacterial properties are outlined in terms of improving the biological properties of PEEK implants. In improving the osseointegration performance of PEEK, surface coating and surface treatment are commonly used modification methods. For surface coating modification, the effects of titanium, titanium dioxide and hydroxyapatite on the osseointegration properties of three coating materials were emphatically expounded, and the spraying process of various coating materials was analyzed. For the surface treatment modification, the surface treatment methods such as plasma spraying, sand blasting, laser etching and concentrated sulfuric acid etching are emphatically expounded, and the advantages and disadvantages of various surface treatment methods are analyzed. In terms of improving the antibacterial properties of PEEK, the use of antibiotics and metallic silver ions to improve the antibacterial properties of PEEK was mainly reviewed. Since the release concentration of silver ions is too high, it will lead to cytotoxicity, and the research on how to control the release rate of silver ions is emphasized. The above various modification methods of PEEK have certain limitations in terms of stability and safety. To truly realize the wide application of modified PEEK in the field of implantation, it is necessary to improve the research on the effect of surface morphology on osseointegration and more Clinical Trials. Finally, the future research of PEEK bone implants is prospected. |
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