朱凯悦,朱丽娜,底月兰,王海斗,段天南.钛合金表面主−被动抑菌改性方法研究进展[J].表面技术,2024,53(1):1-14.
ZHU Kaiyue,ZHU Lina,DI Yuelan,WANG Haidou,DUAN Tiannan.Research Progress of Active-passive Antibacterial Modification of Titanium Alloy Surface[J].Surface Technology,2024,53(1):1-14
钛合金表面主−被动抑菌改性方法研究进展
Research Progress of Active-passive Antibacterial Modification of Titanium Alloy Surface
投稿时间:2022-11-08  修订日期:2023-04-28
DOI:10.16490/j.cnki.issn.1001-3660.2024.01.001
中文关键词:  钛合金  医疗器械  表面改性  抑菌  超疏水表面  纳米粒子
英文关键词:titanium alloy  medical equipment  bacteriostasis  surface modification  superhydrophobic surface  nanoparticles
基金项目:国家自然科学基金(52175207,52275218)
作者单位
朱凯悦 中国地质大学北京工程技术学院,北京 100083;陆军装甲兵学院 装备再制造技术国防科技重点实验室 机械产品再制造国家工程研究中心,北京 100072 
朱丽娜 中国地质大学北京工程技术学院,北京 100083 
底月兰 陆军装甲兵学院 装备再制造技术国防科技重点实验室 机械产品再制造国家工程研究中心,北京 100072 
王海斗 中国地质大学北京工程技术学院,北京 100083;陆军装甲兵学院 装备再制造技术国防科技重点实验室 机械产品再制造国家工程研究中心,北京 100072 
段天南 中国地质大学北京工程技术学院,北京 100083;陆军装甲兵学院 装备再制造技术国防科技重点实验室 机械产品再制造国家工程研究中心,北京 100072 
AuthorInstitution
ZHU Kaiyue College of Engineering and Technology, China University of Geosciences Beijing, Beijing 100083, China;National Key Laboratory for Remanufacturing,National Engineering Research Center for Remanufacturing, Academy of Army Armored Forces, Beijing 100072, China 
ZHU Lina College of Engineering and Technology, China University of Geosciences Beijing, Beijing 100083, China 
DI Yuelan National Key Laboratory for Remanufacturing,National Engineering Research Center for Remanufacturing, Academy of Army Armored Forces, Beijing 100072, China 
WANG Haidou College of Engineering and Technology, China University of Geosciences Beijing, Beijing 100083, China;National Key Laboratory for Remanufacturing,National Engineering Research Center for Remanufacturing, Academy of Army Armored Forces, Beijing 100072, China 
DUAN Tiannan College of Engineering and Technology, China University of Geosciences Beijing, Beijing 100083, China;National Key Laboratory for Remanufacturing,National Engineering Research Center for Remanufacturing, Academy of Army Armored Forces, Beijing 100072, China 
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中文摘要:
      钛合金材料具有良好的耐腐蚀性、抗疲劳性和生物相容性,被广泛用于医疗领域,特别是可植入器械。医疗器械的型号多样、结构复杂、局部尺寸较小,且在使用过程中会接触多种媒介,极易黏附污渍,导致微生物的聚集,引发器械感染,安全、可靠的医疗器械是提高救治效率的关键。从细菌生长机制出发,将现有金属材料表面抑菌改性方法归纳为两大类:依靠抗菌涂层主动杀菌的改性方式和控制表面润湿性的被动抑制细菌黏附的改性方式。采用主动改性方式,虽然能从根本上杀死细菌,但是在实际应用中这些杀菌剂存在耐药性、成本高、生物毒性等问题。被动改性方式无法直接杀死细菌,一旦表面被细菌定植,就会失去抑菌效果。为了实现医疗器械表面高效、长时、安全的清洁,研究者提出主–被动协同抑菌改性方法,将化学杀菌方法与抗黏附抑菌方法相结合,充分发挥2种方法的优势,这是未来研究的重点。
英文摘要:
      Titanium alloy materials have good corrosion resistance, fatigue resistance and biocompatibility, and are widely used in the medical field, especially in implantable devices. Medical equipment has a variety of models, complex structures and small local dimensions. When exposed to various media during use, they are easy to attach stains, causing microbial aggregation and equipment infection. At present, in clinical practice, implant infection can only be treated through revision surgery, which not only generates expensive medical costs, but also brings great pain to patients. Therefore, safe and reliable medical equipment is the key to improve treatment efficiency. Based on this, starting from the growth mechanism of bacteria, the research status of antibacterial surface modification of titanium alloy medical devices was introduced, the research progress of preparing surface materials with good antibacterial activity was discussed, and the basic principles of two existing antibacterial surface modification methods were summarized, namely, active antibacterial surface modification methods that could directly kill contact bacteria and passive antibacterial surface modification methods that could resist bacterial adhesion. The surface modification methods of active sterilization can be divided into contact type and release type. Antimicrobial peptides (AMP), quaternary ammonium compounds (QACs) and chlorhexidine (CHX) belong to contact bactericides. Their bactericidal effect is mainly because the cations they carry can combine with the lipids in the bacterial cell membrane, destroy the bacterial cell membrane structure, and affect the permeability of the cell membrane. Antibiotics and inorganic metal nanoparticles are release bactericides, which can continuously release bactericides to the surrounding environment. These substances can further destroy the internal structure of bacteria after entering the bacterial cells. The passive surface modification method is to control the surface wettability and construct super hydrophobic or super hydrophilic surfaces, both of which have been proved to reduce the adhesion of bacteria on the surface. Super hydrophilic surface is usually modified by hydrophilic polymer materials, such as hydrogel, polyethylene glycol (PEG) and zwitterionic polymer. Their high surface energy enables them to closely combine with water molecules in the environment to form an interface hydration layer to further resist bacterial adhesion. However, the stability of these hydrophilic polymers is poor, and they are easy to decompose and fail in complex working environment. The surface with bionic super hydrophobic structure can reduce the contact between substrate and bacterial solution through the air layer trapped in its microstructure, so as to reduce the bacterial adhesion rate. Although the surface modified by active methods can fundamentally kill bacteria, in practical applications, these bactericides have caused problems such as bacterial resistance, high cost, biological toxicity and hemolysis. Passive surface modification does not prevent bacterial adhesion. Once adhesion occurs, the ability to resist bacteria will be lost. In order to overcome the limitations of a single method, it is necessary to design a surface antibacterial modification method with bactericidal and anti-adhesive effects to achieve efficient, long-term and safe cleaning of the surface of medical devices. The researchers have proposed an active-passive synergistic antibacterial modification method. The combination of chemical sterilization and structural bacteriostasis, giving full play to the advantages of the two methods, is the focus of future research.
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