刘雨晗,刘德,王意,王虎鸣,曹攀.多巴胺表面修饰在医疗领域的研究进展[J].表面技术,2022,51(11):164-173.
LIU Yu-han,LIU De,WANG Yi,WANG Hu-ming,CAO Pan.Research Progress of the Surface Modification by Dopamine in Medical Field[J].Surface Technology,2022,51(11):164-173
多巴胺表面修饰在医疗领域的研究进展
Research Progress of the Surface Modification by Dopamine in Medical Field
  
DOI:10.16490/j.cnki.issn.1001-3660.2022.11.014
中文关键词:  多巴胺  聚多巴胺  表面修饰  医疗器械  人体植入材料
英文关键词:dopamine  polydopamine  surface modification  medical apparatus  medical implant materials
基金项目:国家自然科学基金项目(51905468);江苏省自然科学基金项目(BK20190916)
作者单位
刘雨晗 扬州大学 机械工程学院 表面工程研究所,江苏 扬州 225127 
刘德 扬州大学 机械工程学院 表面工程研究所,江苏 扬州 225127 
王意 扬州大学 机械工程学院 表面工程研究所,江苏 扬州 225127 
王虎鸣 扬州大学 机械工程学院 表面工程研究所,江苏 扬州 225127 
曹攀 扬州大学 机械工程学院 表面工程研究所,江苏 扬州 225127 
AuthorInstitution
LIU Yu-han Institute of Surface Engineering, School of Mechanical Engineering, Yangzhou University, Jiangsu Yangzhou 225127, China 
LIU De Institute of Surface Engineering, School of Mechanical Engineering, Yangzhou University, Jiangsu Yangzhou 225127, China 
WANG Yi Institute of Surface Engineering, School of Mechanical Engineering, Yangzhou University, Jiangsu Yangzhou 225127, China 
WANG Hu-ming Institute of Surface Engineering, School of Mechanical Engineering, Yangzhou University, Jiangsu Yangzhou 225127, China 
CAO Pan Institute of Surface Engineering, School of Mechanical Engineering, Yangzhou University, Jiangsu Yangzhou 225127, China 
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中文摘要:
      多巴胺(DA)及其聚合物聚多巴胺(PDA)含有邻苯二酚基团、氨基等大量活性官能团,使其具有良好的黏附性、生物相容性、反应活性和还原性,被广泛用于医疗器械材料、船舶材料、传感器件材料、药物运输等材料表面的改性,其中对医疗器械材料表面的修饰研究前景尤为广阔。分析了多巴胺的理化特性及相关功能,归纳了多巴胺在生物工程材料上的应用,包括增强材料的骨组织再生能力和提高材料表面细胞的黏附、增殖等。在此基础上,重点综述了近年来多巴胺在医疗领域的改性研究进展,其中多巴胺对骨修复及骨移植材料的修饰包括复合材料和高分子材料等,多巴胺对牙种植体及牙修复材料的修饰包括纳米金属材料和合金材料等,多巴胺对新型医疗材料的修饰包括人工血管、人工韧带材料和医用膜材料等。阐述了改性材料的优缺点和作用,以及多巴胺如何对材料表面进行改性来弥补材料的缺陷。针对不同材料的多巴胺改性,分别从制备方法、实验对比结果等方面进行归纳。最后展望了多巴胺表面修饰技术的发展方向。
英文摘要:
      Dopamine (DA) and polydopamine (PDA) contain a large number of active and hydrophilic functional groups like catechol groups and amino groups. Therefore, they possess many properties such as strong adhesive property, good biocompatibility, outstanding reactivity and reducibility and they are widely used for surface modification of medical device materials, ship materials, sensor materials, drug transportation materials, etc. Among them, the research prospects for the surface modification of medical device materials are particularly broad. materials. This article analyzes the various properties and functions of dopamine, and summarizes the specific application of dopamine in bioengineering materials such as enhancing the bone tissue regeneration ability of the material and improving the adhesion and proliferation of cells on the surface of the material. On this basis, the manuscript focuses on the research progress of dopamine modification in the medical field in recent years. Explains the advantages, disadvantages and functions of each material, and how dopamine's characteristics modify the surface of the material to make up for the defects of the material. In view of the dopamine modification of different materials, the preparation methods and experimental comparison results were summarized. The future perspectives of dopamine surface modification technology are discussed rationally at the end. The modification of dopamine on bone repair and bone graft materials includes composite materials and polymer materials, etc.; Dopamine on dental implants and dental restoration materials Modifications include nano-metal materials and alloy materials; the modification of new medical materials by dopamine includes artificial blood vessels, artificial ligament materials and medical membrane materials. In most articles, dopamine coatings are prepared in much the same way. Dopamine is added to Tris-HCl buffer, and then the material is soaked in solution to form a film of dopamine on the surface of the material. Due to its excellent adhesion and chemical reaction activity, dopamine can be used as a bridge between engineered scaffolds and cells, effectively promoting the adhesion and proliferation of cells on the surface of scaffolds and improving the adhesion of cells on the surface of bone repair materials. Due to the large number of active functional groups, such as catechol groups and amino groups, dopamine can combine bone repair materials with growth factors through covalent bond or non-covalent bond, and the binding force of the two is significantly improved, thus enhancing the regeneration ability of bone tissue. Due to its good adhesion, dopamine can improve the regeneration ability of the bone tissue by guiding the surface mineralization of the scaffold material, so as to slow down the occurrence of the stress shielding phenomenon of the scaffold. Dopamine contains a large number of amino, hydroxyl and other hydrophilic groups. By adding hydrophilic groups on the hydrophobic surface of the material, dopamine can improve the hydrophilic properties of the material, thus improving cell adhesion and proliferation, making artificial blood vessels, artificial ligaments and other materials more suitable for medical applications. Dopamine can undergo oxidation self-polymerization under weak alkaline conditions with dissolved oxygen, forming a biocompatible polydopamine coating on the surface of the material. Polydopamine coatings can react with compounds containing groups such as amino groups and thiols through the structure of phthalol to form a strong and stable chemical bond, and antibiotic drugs can be grafted to the surface of the material by polydopamine coupling. The surface of dopamine-modified medical devices has the disadvantages of adhesion, friction resistance, antibacterial broad spectrum and insufficient timeliness. In order to overcome the above shortcomings, it is necessary to improve the timeliness of dopamine modification coatings from the dopamine polymerization and adhesion mechanism, and incorporate antibacterial and antifouling organic matter on the basis of not affecting its biocompatibility, so as to improve the broad spectrum and adhesion of the anti-biofilm.
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