任浩征,潘超,许迎,孙小淏,刘德宝.ZnO表面改性Zn-Cu组织工程支架的研究[J].表面技术,2021,50(2):58-65.
REN Hao-zheng,PAN Chao,XU Ying,SUN Xiao-hao,LIU De-bao.Study on Zn-Cu Tissue Engineering Scaffolds Surface Modified by ZnO[J].Surface Technology,2021,50(2):58-65 |
| ZnO表面改性Zn-Cu组织工程支架的研究 |
| Study on Zn-Cu Tissue Engineering Scaffolds Surface Modified by ZnO |
| 投稿时间：2020-10-23 修订日期：2020-12-23 |
| DOI：10.16490/j.cnki.issn.1001-3660.2021.02.007 |
| 中文关键词: Zn-Cu合金 多孔支架 ZnO涂层 亲水性 抗菌性能 |
| 英文关键词:Zn-Cu alloy porous scaffolds ZnO coating hydrophilicity antibacterial properties |
| 基金项目:国家自然科学基金项目(51871166) |
| 作者 | 单位 |
| 任浩征 | 天津理工大学 材料科学与工程学院，天津 300384 |
| 潘超 | 天津理工大学 材料科学与工程学院，天津 300384 |
| 许迎 | 天津理工大学 材料科学与工程学院，天津 300384 |
| 孙小淏 | 天津理工大学 材料科学与工程学院，天津 300384 |
| 刘德宝 | 天津理工大学 材料科学与工程学院，天津 300384 |
|
| Author | Institution |
| REN Hao-zheng | College of Material Science and Engineering, Tianjin University of Technology, Tianjin 300384, China |
| PAN Chao | College of Material Science and Engineering, Tianjin University of Technology, Tianjin 300384, China |
| XU Ying | College of Material Science and Engineering, Tianjin University of Technology, Tianjin 300384, China |
| SUN Xiao-hao | College of Material Science and Engineering, Tianjin University of Technology, Tianjin 300384, China |
| LIU De-bao | College of Material Science and Engineering, Tianjin University of Technology, Tianjin 300384, China |
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| 中文摘要: |
| 目的 利用ZnO对Zn-Cu组织支架材料进行表面改性，以提高其亲水性和抑菌、抗菌性能。方法 采用气压渗流铸造法制备了理论孔隙率约为60%的Zn-xCu(x=0,1,2,3)合金组织工程支架，并利用水热法对Zn-xCu(x=0,1,2,3)组织工程多孔支架进行ZnO表面修饰。采用扫描电子显微镜、X射线衍射仪，对制备的多孔支架宏微观形貌、相组成进行了表征。通过滴液法测定样品表面接触角，评价了材料表面的亲/疏水性。采用细菌铺板法研究了ZnO表面修饰前后支架材料的抑菌、抗菌性能。结果 制备的支架体孔洞分布均匀，连通性良好。没有ZnO表面修饰的支架材料表面表现为强疏水性，利用ZnO进行表面改性后，支架材料的表面润湿性能明显改善。修饰后的Zn-3Cu支架抑菌效果更优，未经ZnO表面修饰的Zn-3Cu合金支架的有效灭菌最长距离为7.8 mm，经ZnO表面修饰后的Zn-3Cu合金支架的有效灭菌最长距离为9.8 mm，并且修饰后的Zn-3Cu支架材料浸提液与菌液共培养后分别划线与涂布，与空白菌液相比，菌落稀疏松散。结论 利用气压渗流铸造结合ZnO表面修饰的方法，可制备出具备一定抗菌性能且材料表面呈亲水性的Zn-Cu合金组织工程支架。 |
| 英文摘要: |
| Modern tissue scaffolds materials are not only required to possess a certain mechanical properties and excellent biocompatibility, but also required to have a surface presenting good hydrophilicity and certain antibacterial properties. In this work, Zn-xCu (x=0,1,2,3) alloy tissue engineering scaffolds with theoretical porosity of 60% were successfully prepared by using air pressure infiltration method (APIM) and the surface of Zn-xCu (x=0,1,2,3) tissue engineering porous scaffolds were modified with ZnO by hydrothermal method. The macrostructures, microstructures and phase composition of the porous scaffolds were characterized by means of a field emission scanning electron microscope and X-ray diffractometer respectively. The hydrophilicity/hydrophobicity of the material surface was evaluated by measuring the contact angle between the material surface and water by drop method. The antibacterial properties of the scaffolds materials before and after the surface modification of ZnO were studied by using the bacterial paving method. The results show that:the pores are interconnected and distributed homogeneously within all the prepared scaffolds; the surface of the scaffolds without ZnO modification shows strong hydrophobicity, and the wettability of the scaffolds modified with ZnO is significantly improved; and the modified Zn-3Cu scaffolds have better antibacterial properties. The longest effective distance of Zn-3Cu scaffolds without ZnO surface modification is 7.8 mm, and the longest effective distance of Zn-3Cu scaffolds after ZnO surface modification is 9.8 mm. In addition, compared with the blank control bacterial solution, the modified Zn-3Cu scaffolds material extract co-cultured with the bacterial solution, has sparse and loose bacterial colony after scribing and coating. Therefore, Zn-Cu alloy tissue engineering scaffolds with certain antibacterial properties and hydrophilic surface can be prepared by using the APIM with ZnO surface modification. |
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