曲彦儒,张昊雷,沈传凯,崔东元,丁小康.新型多功能季铵化抗菌材料的制备与应用[J].表面技术,2019,48(7):220-228.
QU Yan-ru,ZHANG Hao-lei,SHEN Chuan-kai,CUI Dong-yuan,DING Xiao-kang.Preparation and Application of Novel Multifunctional Quaternary Ammonium Polymers Antibacterial Materials[J].Surface Technology,2019,48(7):220-228 |
| 新型多功能季铵化抗菌材料的制备与应用 |
| Preparation and Application of Novel Multifunctional Quaternary Ammonium Polymers Antibacterial Materials |
| 投稿时间：2018-11-08 修订日期：2019-07-20 |
| DOI：10.16490/j.cnki.issn.1001-3660.2019.07.024 |
| 中文关键词: 季铵化高分子 多功能抗菌材料 抗污 超亲水 促凝血 促细胞生长 |
| 英文关键词:quaternary ammonium polymers multifunctional antibacterial materials anti-fouling super-hydrophilic blood coagulation cell proliferation |
| 基金项目:国家自然科学基金资助项目（51573014，21504006） |
| 作者 | 单位 |
| 曲彦儒 | 北京化工大学，北京 100029 |
| 张昊雷 | 北京化工大学，北京 100029 |
| 沈传凯 | 北京化工大学，北京 100029 |
| 崔东元 | 北京化工大学，北京 100029 |
| 丁小康 | 北京化工大学，北京 100029 |
|
| Author | Institution |
| QU Yan-ru | Beijing University of Chemical Technology, Beijing 100029, China |
| ZHANG Hao-lei | Beijing University of Chemical Technology, Beijing 100029, China |
| SHEN Chuan-kai | Beijing University of Chemical Technology, Beijing 100029, China |
| CUI Dong-yuan | Beijing University of Chemical Technology, Beijing 100029, China |
| DING Xiao-kang | Beijing University of Chemical Technology, Beijing 100029, China |
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| 中文摘要: |
| 综述了近年来在抗污、超滑/超亲水、可降解、促凝血、促细胞生长等新型多功能季铵化抗菌材料的分子设计和潜在应用方面取得的研究进展，指出在抗菌的同时并具有以上所提及的多种功能是抗菌材料发展的一大趋势。举例说明通过原子转移自由基聚合（ATRP）技术，合成的星状聚合物（POSS-g-PDMA），在季铵化后具有了极高的抗菌活性、相对非血溶性和可降解性。高度季铵化的基于二甲基癸基铵壳聚糖-接枝-聚(乙二醇)甲基丙烯酸酯(DMDC-Q-g-EM)和聚(乙二醇)二丙烯酸酯的抗菌水凝胶兼具抗菌和抗真菌活性、生物相容性和可重复使用性。最后对新型多功能季铵化抗菌材料的未来发展方向进行了展望。 |
| 英文摘要: |
| The research progress in molecular design and potential application of novel multifunctional quaternary ammonium antibacterial materials in recent years, such as anti-fouling, super-slippery/super-hydrophilic property, degradation, blood coagulation promotion, cell growth promotion, etc., was reviewed. The multiple functions mentioned above were also the major trend in the development of antibacterial materials while resisting bacteria. An example was given to illustrate that the star polymer (POSS-g-PDMA) synthesized by atom transfer radical polymerization (ATRP) technology had extremely high antibacterial activity, relatively non-blood solubility and degradability after quaternization. Highly quaternized antibacterial hydrogels based on dimethyl decyl ammonium chitosan-graft-poly (ethylene glycol) methacrylate (DMDC-Q-g-EM) and poly (ethylene glycol) diacrylate had antibacterial and antifungal activities, biocompatibility and reusability. Finally, the future development direction of new multifunctional quaternary ammonium antibacterial materials is prospected. |
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