马欢欢,仇文豪,黄浩,乔阳.聚醚醚酮骨植入体生物改性研究进展[J].表面技术,2023,52(3):111-121.
MA Huan-huan,QIU Wen-hao,HUANG Hao,QIAO Yang.Research Progress in Biological Modification of Polyether-ether-ketone Bone Implants[J].Surface Technology,2023,52(3):111-121
聚醚醚酮骨植入体生物改性研究进展
Research Progress in Biological Modification of Polyether-ether-ketone Bone Implants
  
DOI:10.16490/j.cnki.issn.1001-3660.2023.03.008
中文关键词:  聚醚醚酮  骨植入体  力学性能  骨整合性能  抗菌性能
英文关键词:PEEK  bone implants  mechanical property  osseointegration property  mold resistance
基金项目:山东省自然科学基金(ZR2019QEE032);山东省高等学校青创科技支持计划(2019KJB021);济南市高校自主培养创新团队项目(2019GXRC012)
作者单位
马欢欢 济南大学 机械工程学院,济南 250002 
仇文豪 济南大学 机械工程学院,济南 250002 
黄浩 济南大学 机械工程学院,济南 250002 
乔阳 济南大学 机械工程学院,济南 250002 
AuthorInstitution
MA Huan-huan School of Mechanical Engineering, University of Jinan, Jinan 250002, China 
QIU Wen-hao School of Mechanical Engineering, University of Jinan, Jinan 250002, China 
HUANG Hao School of Mechanical Engineering, University of Jinan, Jinan 250002, China 
QIAO Yang School of Mechanical Engineering, University of Jinan, Jinan 250002, China 
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中文摘要:
      聚醚醚酮是一种热塑性材料,凭其良好的生物相容性和X射线可透射性,被广泛用于生物医学领域。而PEEK骨植入体与人体骨骼强度存在一定差距,与人体骨组织结合能力较差和抗菌性能等不足,使其在生物领域的应用受到了限制。为了使PEEK更好地应用于人体骨植入领域,获得优异生物性能的PEEK骨植入体已成为研究的重点。概述了PEEK的加工技术、力学性能、骨整合性能和抗菌性能的研究。在此基础上,重点综述了近年来提高PEEK骨植入体力学性能与生物性能的各种改性方法的研究进展。在力学性能方面,对PEEK常用的填充材料碳纤维进行了概述,由于PEEK与碳纤维界面结合强度影响其整体力学性能,重点介绍了提高其结合强度的改性方法。在骨整合性能方面,对钛、二氧化钛和羟基磷灰石涂层材料及喷涂方法进行了概述,以及对等离子喷涂、喷砂、激光蚀刻和浓硫酸刻蚀表面处理方法的优缺点进行了分析。在抗菌性能方面,银离子释放浓度过高时会导致细胞毒性,重点阐述了如何控制银离子释放速度的研究。最后展望了PEEK骨植入体加工和改性的未来发展方向。
英文摘要:
      Polyether-ether-ketone (PEEK) is a thermoplastic material that is widely used in biomedical fields due to its good biocompatibility and X-ray transmittance. However, there is a certain gap between PEEK implants and human bone strength, and the poor binding ability to human bone tissue and the lack of antibacterial properties limit their application in the biological field. The osseointegration and antibacterial properties of implant materials are critical to the success of human therapy, repair and surgery. In order to make PEEK better used in the field of human bone implantation, obtaining PEEK bone implants with excellent performance has become the focus of research. This paper summarizes the research on the processing technology, mechanical properties, osseointegration properties and antibacterial properties of PEEK. On this basis, the research progress of PEEK processing technology and various modification methods to improve the mechanical properties and biological properties of PEEK in recent years is mainly reviewed. First, the effects of 3D printing and machining on the surface quality of PEEK machined are outlined. In the cutting process, the influence of cutting parameters and cooling medium on the quality of the machined surface is mainly expounded. In 3D printing, the research on the strength and surface quality of printed parts by process parameters such as printing speed, nozzle temperature and heat treatment method is detailed. Secondly, in terms of improving the mechanical properties of PEEK, the carbon fiber filled PEEK is mainly summarized. Due to the chemical inertness of carbon fiber and the high melt viscosity of PEEK, the bonding force between the interface of PEEK and carbon fiber is weak, which affects the overall mechanics of carbon fiber PEEK composites. Therefore, the modification method to improve the force of the bonding surface of PEEK and carbon fiber is emphasized. Thirdly, the osseointegration properties and antibacterial properties are outlined in terms of improving the biological properties of PEEK implants. In improving the osseointegration performance of PEEK, surface coating and surface treatment are commonly used modification methods. For surface coating modification, the effects of titanium, titanium dioxide and hydroxyapatite on the osseointegration properties of three coating materials were emphatically expounded, and the spraying process of various coating materials was analyzed. For the surface treatment modification, the surface treatment methods such as plasma spraying, sand blasting, laser etching and concentrated sulfuric acid etching are emphatically expounded, and the advantages and disadvantages of various surface treatment methods are analyzed. In terms of improving the antibacterial properties of PEEK, the use of antibiotics and metallic silver ions to improve the antibacterial properties of PEEK was mainly reviewed. Since the release concentration of silver ions is too high, it will lead to cytotoxicity, and the research on how to control the release rate of silver ions is emphasized. The above various modification methods of PEEK have certain limitations in terms of stability and safety. To truly realize the wide application of modified PEEK in the field of implantation, it is necessary to improve the research on the effect of surface morphology on osseointegration and more Clinical Trials. Finally, the future research of PEEK bone implants is prospected.
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