刘莹,杨瑞,刘井来,刘佳欣,张靖羚.单相、双相及多相离子掺杂的羟基磷灰石研究进展[J].表面技术,2022,51(10):143-154.
LIU Ying,YANG Rui,LIU Jing-lai,LIU Jia-xin,ZHANG Jing-ling.Hydroxyapatite Nanomaterials Doped with Single-phase,Dual-phase and Multiphase Ions[J].Surface Technology,2022,51(10):143-154
单相、双相及多相离子掺杂的羟基磷灰石研究进展
Hydroxyapatite Nanomaterials Doped with Single-phase,Dual-phase and Multiphase Ions
  
DOI:10.16490/j.cnki.issn.1001-3660.2022.10.014
中文关键词:  羟基磷灰石  离子掺杂  抗菌性  机械强度  植入物涂层  治疗癌症
英文关键词:
基金项目:辽宁省教育厅项目(LJ2020JCL033)
作者单位
刘莹 辽宁工程技术大学 理学院辽宁 阜新123000 
杨瑞 辽宁工程技术大学 材料科学与工程学院,辽宁 阜新123000 
刘井来 甘李药业股份有限公司,北京101102 
刘佳欣 辽宁工程技术大学 材料科学与工程学院,辽宁 阜新123000 
张靖羚 辽宁工程技术大学 材料科学与工程学院,辽宁 阜新123000 
AuthorInstitution
LIU Ying College of Science,Liaoning Fuxin 123000, China 
YANG Rui College of Materials Science and Engineering, Liaoning Technical University, Liaoning Fuxin 123000, China 
LIU Jing-lai Ganli Pharmaceutical Co., Ltd., Beijing 101102, China 
LIU Jia-xin College of Materials Science and Engineering, Liaoning Technical University, Liaoning Fuxin 123000, China 
ZHANG Jing-ling College of Materials Science and Engineering, Liaoning Technical University, Liaoning Fuxin 123000, China 
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中文摘要:
      羟基磷灰石是天然骨组织成分中的重要组成部分,一直是生物医学领域关注和研究的重点。天然骨成分中的磷灰石,是一种结合着多种离子的羟基磷灰石,维持着生命系统的正常生长与发育。本研究阐述了羟基磷灰石的晶体结构;概述了研究者针对羟基磷灰石性能探究,其中包括生物相容性、生物活性、适宜的机械强度、优异的成骨性能和耐腐蚀性能。同时归纳了离子掺杂羟基磷灰石取代位点。在此基础上,重点阐述了近五年来单相、双相以及多相掺杂羟基磷灰石材料的研究,其中包括单相、双相以及多相离子掺杂对羟基磷灰石在结构性能、机械强度、抗菌性、降解性和成骨性等性能的影响,同时简单总结了离子掺杂对机械强度的影响规律。近年来虽然羟基磷灰石生物陶瓷材料在临床上作为植入物涂层、缓释药物的载体、骨移植物代替材料等被应用,但在临床方面广泛运用还面临着许多问题与挑战,所以本文同时展望了离子掺杂羟基磷灰石未来的的发展方向,有望在临床应用及发展方面有一定的指导意义。
英文摘要:
      Hydroxyapatite is an important part of natural bone tissue composition and has always been the focus of attention and research in the field of biomedicine. The apatite in the natural bone composition is a kind of hydroxyapatite combined with a variety of ions, which maintains the normal growth and development of life systems. With the systematic research on single-phase ion doping, the preparation and performance of dual-phase and multi-phase doped hydroxyapatite are being continuously expanded. The preparation and performance of phase and heterogeneous ion-doped hydroxyapatite are systematically elaborated and summarized.This study expounds the crystal structure of hydroxyapatite, describes the advantages and performance advantages of synthetic hydroxyapatite itself, hydroxyapatite with good biological properties as a coating has been widely used in experiments to replace bone, but Some performance deficiencies limit its application. The study outlines the researchers' research on the effects of different ion doping or different forms of doping on the properties of hydroxyapatite, including biocompatibility, biological activity, suitable mechanical strength, excellent bone formation performance and corrosion resistance performance. At the same time, the different substitution sites of anion and cation doped hydroxyapatite are summarized.On this basis, starting from the preparation and performance research of single-phase ion-doped hydroxyapatite, the performance changes caused by different ion doping and the corresponding mechanism are explained. Prospects and shortcomings. Based on the single-phase ion-doped hydroxyapatite in the past five years, it is necessary to explore the effects of two-phase and multi-phase ion-doped hydroxyapatite on the structural properties, mechanical strength, antibacterial properties, degradability, and osteogenic properties. A certain pavement. At the same time, two-phase and multi-phase ion doping of hydroxyapatite found that the doping ions will promote each other. By doping hydroxyapatite in different phases, it is found that the performance of multi-phase doping is based on the synergistic effect of single-phase or multi-phase doping. In addition, the doping of hydroxyapatite with trace ions can promote the activity of bone cells, promote the growth, proliferation and differentiation of bone cells, and thus play a role in inducing bone formation. However, doping with different ions will produce different properties. The doping of hydroxyapatite with magnesium, iron, zinc, strontium, and fluorine will produce different degrees of antibacterial properties against Escherichia coli or Staphylococcus aureus. Part of the ions doped with hydroxyapatite will increase the mechanical properties of the material and increase the degradation performance.Through more systematic preparation and performance research of single-phase and dual-phase doped hydroxyapatite, a more effective preparation method has been explored for realizing multiphase doped hydroxyapatite. In recent years, although hydroxyapatite bioceramic materials have been used clinically as implant coatings, sustained-release drug carriers, and bone graft replacement materials, they still face many problems and challenges in their widespread use in clinical practice. Therefore, this article also looks forward to the future development direction of ion-doped hydroxyapatite, paving the way for exploring the preparation method and performance of heterogeneous ion-doped hydroxyapatite, making the preparation closer to natural crystal structure and performance The bionic bone material of apatite is expected to have certain guiding significance in clinical application and development.
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