李昱彤,裴佳,袁广银.材料表面微纳形貌对血管细胞行为影响的研究综述[J].表面技术,2019,48(7):332-339.
LI Yu-tong,PEI Jia,YUAN Guang-yin.Review on Influence of Micro-nano Scale Surface Topography on Vascular Cells Responses[J].Surface Technology,2019,48(7):332-339 |
| 材料表面微纳形貌对血管细胞行为影响的研究综述 |
| Review on Influence of Micro-nano Scale Surface Topography on Vascular Cells Responses |
| 投稿时间：2019-01-15 修订日期：2019-07-20 |
| DOI：10.16490/j.cnki.issn.1001-3660.2019.07.038 |
| 中文关键词: 镁合金血管支架 支架再内皮化 表面微纳形貌 血管内皮细胞 血管平滑肌细胞 |
| 英文关键词:magnesium alloy vascular stent stent re-endothelialization micro-nano scale surface topography vascular en-dothelial cells vascular smooth muscle cells |
| 基金项目:国家自然科学基金（51701041） |
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| Author | Institution |
| LI Yu-tong | The State Key Lab of Metal Matrix Composites, National Engineering Research Center of Light Alloy Net Forming, School of Materials Science and Engineering, Shanghai Jiaotong University, Shanghai 200240, China |
| PEI Jia | The State Key Lab of Metal Matrix Composites, National Engineering Research Center of Light Alloy Net Forming, School of Materials Science and Engineering, Shanghai Jiaotong University, Shanghai 200240, China |
| YUAN Guang-yin | The State Key Lab of Metal Matrix Composites, National Engineering Research Center of Light Alloy Net Forming, School of Materials Science and Engineering, Shanghai Jiaotong University, Shanghai 200240, China |
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| 中文摘要: |
| 镁合金具有良好的生物相容性、优良的力学性能以及可完全降解的特点，是制备血管支架的理想材料。然而在支架植入初期，支架表面平滑肌细胞增殖速率超过内皮细胞增殖速率，导致支架内再狭窄的发生。近年来，在材料表面构筑微纳尺度形貌，通过调控血管内皮细胞和平滑肌细胞行为，实现支架表面快速内皮化成为一种新的研究思路。从基底材料、形貌特征、制备工艺、细胞种类以及实验结果等方面，系统地总结了近年来关于材料表面微纳形貌对血管细胞行为的影响。因为目前镁合金表面微纳形貌对血管细胞行为影响的报道尚少，从镁合金种类、形貌制备工艺、形貌特征以及形貌功能等方面详细整理了不同研究领域，在镁合金表面制备微纳形貌的相关研究。与此同时，分析了在镁基血管支架表面制备微纳尺度形貌用于实现支架表面快速内皮化研究所面临的挑战，并介绍了本课题组相关研究工作进展。 |
| 英文摘要: |
| Magnesium alloys are promising materials to prepare the vascular stent due to the favorable biocompatibility, ex-cellent mechanical properties and perfect biodegradable property. However, in-stent restenosis (ISR) still remains in the primary stage of implantation because of the excessive proliferation of vascular smooth muscle cells (SMCs) over endothelial cells (ECs). Recently, micro-nano scale surface topography construction provides a prospective strategy for rapid re-endothelialization via regulating the behavior of both ECs and SMCs. The work systematically summarized the influence of micro-nano surface topography on vascular cells from the aspects of substrate materials, topography features, preparation methods, cell types and test results. As there were few reports on the influence of micro-nano surface topography of magnesium alloys on the cell responses, relevant researches on fabrication of micro-nano topography on magnesium alloys surface in different fields were introduced in detail from type of magnesium alloy, topography fabrication process, topography characteristics, topography functions, etc. Meanwhile, the challenges of applying micro-nano scale topography to promote rapid re-endothelialization of Mg-based vascular stents were analyzed and the corresponding research progress in the research group was presented. |
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