任冰,万熠,王桂森,王滕,曹恩源.医用钛合金表面形貌与成分对生物相容性影响研究综述[J].表面技术,2018,47(4):160-171.
REN Bing,WAN Yi,WANG Gui-sen,WANG Teng,CAO En-yuan.Effects of Surface Morphology and Composition of Medical Titanium Alloys on Biocompatibility[J].Surface Technology,2018,47(4):160-171
医用钛合金表面形貌与成分对生物相容性影响研究综述
Effects of Surface Morphology and Composition of Medical Titanium Alloys on Biocompatibility
投稿时间:2017-05-01  修订日期:2018-04-20
DOI:10.16490/j.cnki.issn.1001-3660.2018.04.024
中文关键词:  钛合金  植入体  表面改性  微纳结构  氧化膜  生物相容性  抗腐蚀性
英文关键词:titanium  implants  surface modification  micro/nano-structure  oxide film  biocompatibility  corrosion resistance
基金项目:国家自然科学基金资助项目(51575320)
作者单位
任冰 山东大学 高效洁净机械制造教育部重点实验室,济南 250061 
万熠 山东大学 高效洁净机械制造教育部重点实验室,济南 250061 
王桂森 山东大学 高效洁净机械制造教育部重点实验室,济南 250061 
王滕 山东大学 高效洁净机械制造教育部重点实验室,济南 250061 
曹恩源 电子科技大学,成都 611731 
AuthorInstitution
REN Bing Key Laboratory of Ministry of Education for High-efficiency and Clean Mechanical Manufacture, Shandong University, Jinan 250061, China 
WAN Yi Key Laboratory of Ministry of Education for High-efficiency and Clean Mechanical Manufacture, Shandong University, Jinan 250061, China 
WANG Gui-sen Key Laboratory of Ministry of Education for High-efficiency and Clean Mechanical Manufacture, Shandong University, Jinan 250061, China 
WANG Teng Key Laboratory of Ministry of Education for High-efficiency and Clean Mechanical Manufacture, Shandong University, Jinan 250061, China 
CAO En-yuan University of Electronic Science and Technology of China, Chengdu 611731, China 
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中文摘要:
      生物医用钛合金表面物化特性作为影响细胞生物学行为的关键因素,决定了骨-植入体之间的结合质量和速率。针对作者所在研究小组在钛合金表面改性技术研究中所取得的一系列进展进行了综述。在表面形貌制备方面,利用喷砂、激光和微细铣削等机械加工方法和酸蚀、碱热处理、阳极氧化等化学处理方法,在钛合金表面获得了微纳米双级结构。在表面化学成分方面,采用离子置换的方式在微纳米结构表面植入生物活性离子,通过富氧切削方式改善表面钝化膜的质量。通过电化学腐蚀试验和一系列体外细胞培养实验,验证各表面物化改性方法对钛合金植入体生物相容性的影响。研究表明,微纳米结构化的表面能够提高材料表面的亲水性,促进细胞的粘附、增殖和矿化等,而植入生物活性离子后与微纳结构表面产生了协同效应,进一步增加了其生物相容性。此外,在富氧加工气氛下,钛合金表面的氧化膜厚度相比自然条件下加工有明显增加,提高了生物相容性,同时耐腐蚀性也得到显著增强。
英文摘要:
      As a key factor affecting the biological behavior of cells, physicochemical surface properties of biomedical titanium alloy determine the bone-implant bonding quality and the rates of integration. The work aims to review a series of advances of our group in the research of surface modification technology on titanium alloy. For preparation of surface morphology, the micro/nano- hierarchical structure was obtained on the surface of titanium alloy by both mechanical processing such as sandblasting, laser processing and micro-milling and chemical treatment including acid etching, alkali heat treatment and anodizing. For the surface chemical composition, bioactive ions were implanted on the micro/nano-structured surface by ion exchange; the quality of surface passivation film was improved using the oxygen-rich cutting method. The effects of surface modification methods on the biocompatibility of titanium implants were verified by electrochemical corrosion tests and a series of cell culturing experiments in vitro. According to the results, the micro/nano-structured surface can improve the wettability of the material and promote the cell adhesion, proliferation and mineralization. Besides, the implantation of bioactive ions further enhances the biocompatibility of implants because of the synergistic effect with the micro/nano-structure. In addition, the thickness of oxide film on titanium alloy surface increases significantly in the oxygen-rich processing atmosphere compared to the natural condition, which improves the biocompatibility of and corrosion resistance simultaneously.
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