朱洪强,何宏燕,袁媛,刘昌胜.钛基体表面多级孔洞结构的制备和生物活性研究[J].表面技术,2015,44(7):56-60,67.
ZHU Hong-qiang,HE Hong-yan,YUAN Yuan,LIU Chang-sheng.Preparation of Hierarchical Porous Structure on Ti Surface and Bioactivity[J].Surface Technology,2015,44(7):56-60,67
钛基体表面多级孔洞结构的制备和生物活性研究
Preparation of Hierarchical Porous Structure on Ti Surface and Bioactivity
投稿时间:2015-04-28  修订日期:2015-07-20
DOI:10.16490/j.cnki.issn.1001-3660.2015.07.011
中文关键词:  钛基体  多级孔洞结构  碱热处理  羟基磷灰石  生物活性
英文关键词:titanium  hierarchical porous structure  alkali heat treatment  hydroxyapatite  bioactivity
基金项目:上海市自然科学基金项目(#14ZR1409800)
作者单位
朱洪强 华东理工大学 超细材料制备与应用教育部重点实验室, 上海 200237 
何宏燕 华东理工大学 超细材料制备与应用教育部重点实验室, 上海 200237 
袁媛 华东理工大学 超细材料制备与应用教育部重点实验室, 上海 200237 
刘昌胜 华东理工大学 超细材料制备与应用教育部重点实验室, 上海 200237 
AuthorInstitution
ZHU Hong-qiang Key Laboratory for Ultrafine Materials of Ministry of Education,East China University of Science and Technology, Shanghai 200237, China 
HE Hong-yan Key Laboratory for Ultrafine Materials of Ministry of Education,East China University of Science and Technology, Shanghai 200237, China 
YUAN Yuan Key Laboratory for Ultrafine Materials of Ministry of Education,East China University of Science and Technology, Shanghai 200237, China 
LIU Chang-sheng Key Laboratory for Ultrafine Materials of Ministry of Education,East China University of Science and Technology, Shanghai 200237, China 
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中文摘要:
      目的 通过调控钛基体表面的结构和特性,提高惰性钛基体表面的生物活性,改善其医用植入效果。 方法 采用碱热处理方法在钛基体表面构建多级孔洞结构,对改性后钛片的表面形貌、成分、结构、亲疏水性进行表征,评价钛片表面对类骨磷灰石的诱导能力。 结果 碱热处理使钛表面形成了多孔网状结构,孔洞包括微米级孔和 200 ~300 nm 的纳米孔,孔隙间隔介于微米至几百纳米之间。 碱热处理后的钛片表面形成了含有大量羟基的氧化物层,主要成分为金红石型 TiO2 和碱性钛酸盐,具有极好的亲水性,接触角仅约为 12°。 碱热处理钛片表面的三维多孔结构对磷灰石的生长有很好的诱导作用,矿化 7天后,类骨磷灰石便完全覆盖表面,14 天后的矿化效果更好。 结论 纯钛表面通过碱热处理法构建微纳多孔结构后,具有良好的诱导羟基磷灰石形成的能力,对其生物活性有促进作用。
英文摘要:
      Objective To improve the bioactivity of the titanium surface by regulating the surface morphology and properties so as to improve the effect for medical implantation. Methods Alkali heat treatment (AHT) was used to construct the hierarchical porous structure on the titanium surface. The surface morphology, structure, elements, and hydrophilicity of the treated titanium were characterized by a series of analytical tools. The biomimetic mineralization experiments were carried out to evaluate the hydroxyapatite formation on the treated surface in simulated body fluid (SBF). Results It was revealed that the hierarchical porous structure was formed after AHT, the holes included micron holes and 200 ~300 nm hole, the pore intervals varied from microns to hundreds of nanometers. An oxide layer containing a large number of hydroxyl groups was formed on the titanium surface after AHT. Hydrophilic of titanium surface after AHT was excellent, the contact angle was about 12. The alkaline titanate, as well as rutile TiO2 , was the main component of coating. The porous structure exhibited good apatite-inducing ability in SBF. Many bonelike apatite crystals were formed on AHT-titanium surface after 7 d immersion and the mineralization behavior exhibited even better after 14 d. Conclusion AHT-titanium with micro / nano pores exhibits the good inducibility for hydroxyapatite formation, which has a promotion effect on its biological activity.
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